Correlation between ABCB1 and OLIG2 polymorphisms and the severity and prognosis of patients with cerebral infarction.

This study investigated the relationship between ATP-binding cassette sub-family B member 1 (ABCB1) and OLIG2 single nucleotide polymorphism (SNP) and neurological injury severity and outcome in cerebral infarction (CI). The neurological injury severity of 298 CI patients was evaluated by the National Institutes of Health Stroke Scale. The prognosis of CI patients at 30 days after admission was evaluated by the modified Rankin Scale. And 322 healthy people were selected as the control group. The SNPs of the ABCB1 gene (rs1045642) and OLIG2 gene (rs1059004 and rs9653711) were detected by TaqMan probe PCR, and the distribution of SNPs genotype was analyzed. SNP rs9653711 was correlated with CI. Recessive models of rs1045642 and rs9653711 were correlated with CI. The genotypes of rs1045642 and rs9653711 and genetic models were associated with CI severity. rs1045642 had no correlation with CI prognosis, while rs9653711 had less correlation. The genotype distribution and recessive model were associated with CI prognosis. SNP rs1059004 was not associated with CI severity and prognosis. Alcohol consumption, hypertension, diabetes, hyperlipidemia, and high levels of homocysteine (HCY) were independent risk factors for CI, while hypertension, hyperlipidemia, and HCY were associated with poor prognosis of CI. ABCB1 rs1045642 and OLOG2 rs9653711 are associated with CI severity.

A Person-Centered Analysis of Meaning in Life, Purpose Orientations, and Attitudes toward Life among Chinese Youth.

Background: Meaning in life, purpose orientations, and attitudes toward life have a significant impact on youths' well-being. The purpose of this study is to investigate the developmental trends of youths' meaning in life, purpose orientations, and attitudes toward life. Methods: The sample consisted of 94,219 students aged 13 to 23 years (M = 16.67, SD = 2.70). Person-centered analysis, MANOVA, and an independent sample t-test were used to analyze the data. Results: Most youths were in the "search" or "presence" type in terms of meaning in life status. Fewer students were identified as being in the "ruminative exploration" or "diffusion" type. Very few were in the "precontemplation" or "foreclosure" stages. The status of the sense of meaning did not change significantly with age. Second, in terms of purpose orientations, Chinese youths consider family well-being and personal growth to be the most important goals, whereas personal well-being and social promotion are less important. Third, in terms of attitudes toward life, most young people take an active, accepting, and optimistic view of their lives, seeing life as an experience or process, rather than a good or bad result. Fourthly, the age of 16 was found to be a significant turning point. More emerging adults were in the "presence" state than adolescents, but their attitudes toward life were not as positive as those of adolescents. Conclusions: This study reveals that Chinese youth consider the question of meaning in life as early as age 13. Most of them were in the state of "searching for meaning". Therefore, education about meaning in life should be integrated into the primary school context. Family well-being is emphasized by Chinese youth because of the collectivist culture. Family well-being and personal growth should be recognized, and social promotion should be enhanced in guidance of Chinese youth's meaning acquisition.

Cyclization of Vinyl Diazo Compounds with Benzofuran-Derived Azadienes Enabled by NaBArF4.

An unprecedented cycloaddition of vinyl diazo compounds with benzofuran-derived azadienes catalyzed by rarely independently used NaBArF4 has been established. Benzofuran-fused hydropyridines were constructed with excellent yields and high diastereoselectivity via a Na+-catalyzed inverse-electron-demand aza-Diels-Alder reaction. Notably, this transformation also features good compatibility with a one-pot protocol to deliver the spiro[benzofuran-cyclopentene] skeleton, as well as perfect atom economy and simple reaction conditions.

Development and Validation of the Youth Purpose Orientation Scale Among Chinese Sample.

Introduction: Purpose orientation has an important impact on the development of adolescence. An effective instrument is needed to describe the purpose orientation of youth. The aim of this research is to develop a reliable and valid scale to measure life purpose orientations of youth. Methods: Study 1 established a preliminary pool of items based on a literature review, an open-form questionnaire, and some expert opinions. Study 2 used exploratory factor analysis and performed internal consistency and reliability tests. The sample consisted of 442 young Chinese students, divided into males (49.3%) and females (50.7%) with an age range of 13 to 22 years. Study 3 performed confirmatory factor analysis and tested the scale's calibration validity and test-retest reliability. The confirmatory sample comprised 91,635 young Chinese students, divided into males (43.2%) and females (56.5%) with an age range of 12 to 23 years. The calibration validity sample consisted of 572 participants, aged 12 to 22. The test-retest reliability sample consisted of 200 participants. Results: Through exploratory factor analysis, the four-factor structure revealed contains personal growth, social promotion, family well-being, and personal well-being purpose orientations. This four factor-structure revealed a 65.26% cumulative variance. The four factors' alpha reliability was 0.89 for personal growth, 0.87 for social promotion, 0.86 for family well-being, and 0.87 for personal well-being, respectively. Confirmatory factor analysis showed that the model fitting index had a good four-factor structure. The calibration validity and test-retest reliability were acceptable. Conclusion: These findings demonstrated that the 19-item findings demonstrated that the Youth Purpose Orientation Scale is a valid and reliable measure. In future research, it can be used to measure purpose orientation in youth.

The dissociating of reward feedback on familiarity and recollection processing: evidence from event-related potential.

OBJECTIVES: Although previous studies have explored the effect of reward feedback on recognition memory, electrophysiological evidence for reward-enhanced memory and its underlying processing mechanisms remains unclear. METHODS: This study adopts reward-learning and recognition memory tasks. Participants were asked to learn the reward values of two-color images (each color image had either reward or nonreward feedback) in the reward-learning task, and then tested their recognition memory performance with reward and nonreward feedback items. RESULTS: Results demonstrated that the recognition memory performance of rewarded items was better than that of nonrewarded items. During the reward-learning period, nonreward feedback elicited larger feedback-related negativity (FRN) and P300 amplitudes compared with reward feedback. The findings indicated that participants mainly engaged in prediction error processing in the early stage, followed by comparing and context update of the learned items. During the recognition memory period, reward items elicited larger FN400 amplitude and smaller LPC amplitude compared with nonreward items. This suggests that reward item retrieval has deeper memory traces and can identify items faster, relying mainly on familiarity processing. Conversely, nonreward, as a general or inhibitory item, requires more detail and cognitive resources, that is, relies on recollection processing. CONCLUSIONS: These findings indicated that participants had different process patterns between reward and nonreward items during recognition retrieval.

Manganese and dysprosium codoped carbon quantum dots as a potential fluorescent/T1/T2/CT quadri-modal imaging nanoprobe.

It has been challenging to integrate various medical imaging modalities into an ultra-small nanoparticle with good biocompatibility to build highly efficient multimodal imaging nanoprobes. A new manganese and dysprosium codoped carbon quantum dots (Mn,Dy-CQDs) with a mean diameter of 1.77 nm was synthesized for fluorescence imaging,T1/T2-weighted magnetic resonance imaging (T1/T2-weighted MRI), and x-ray computed tomography (CT) imaging using a simple one-step hydrothermal approach. The obtained Mn,Dy-CQDs showed good water solubility, long-term stability, strong stable fluorescence property (fluorescence quantum yield of 31.62%), and excellent biocompatibility. The cell imaging verified that the Mn,Dy-CQDs have high efficiency of fluorescence imaging. The Mn,Dy-CQDs, on the other hand, had a superior x-ray absorption performance (47.344 HU l g-1), a higher longitudinal relaxivity (r1 = 7.47 mM-1s-1), a higher transverse relaxivity (r2 = 42.686 mM-1s-1).In vitroT1/T2-weighted MRI and CT imaging showed that Mn,Dy-CQDs can produce a strong contrast enhancement impact. To summarise, the Mn,Dy-CQDs may be used as aT1/T2-weighted MRI/CT/fluorescent quadri-modal imaging nanoprobe, indicating that they have a lot of uses in biomedical multimode imaging and clinics.